Diprivan (propofol) dosing, indications, interactions, adverse effects, and more (2023)

  • abametapir

    abametapir will increase the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Avoid or Use Alternate Drug. For 2 weeks after abametapir application, avoid taking drugs that are CYP2B6 substrates. If not feasible, avoid use of abametapir.

  • benzhydrocodone/acetaminophen

    benzhydrocodone/acetaminophen, propofol.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).

  • calcium/magnesium/potassium/sodium oxybates

    propofol, calcium/magnesium/potassium/sodium oxybates.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • carbamazepine

    carbamazepine will decrease the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Avoid or Use Alternate Drug.

  • ceritinib

    ceritinib increases levels of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Avoid concurrent use of CYP2C9 substrates known to have narrow therapeutic indices or substrates primarily metabolized by CYP2C9 during treatment with ceritinib; if use of these medications is unavoidable, consider dose.

  • doxapram

    doxapram, propofol. Mechanism: unspecified interaction mechanism. Contraindicated. May result in V tach or V fib. Delay doxapram until anesthesia has been excreted.

  • epinephrine

    propofol increases levels of epinephrine by unknown mechanism. Avoid or Use Alternate Drug.

  • epinephrine racemic

    propofol increases levels of epinephrine racemic by unknown mechanism. Avoid or Use Alternate Drug.

  • fedratinib

    propofol will increase the level or effect of fedratinib by Other (see comment). Avoid or Use Alternate Drug. Avoid coadministration of fedratinib (a CYP3A4 and CYP2C19 substrate) with dual CYP3A4 and CYP2C19 inhibitor. Effect of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib has not been studied.

  • fentanyl

    fentanyl, propofol.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl intranasal

    fentanyl intranasal, propofol.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl transdermal

    fentanyl transdermal, propofol.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fentanyl transmucosal

    fentanyl transmucosal, propofol.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Consider dose reduction of either or both agents to avoid serious adverse effects. Monitor for hypotension, respiratory depression, and profound sedation.

  • fexinidazole

    fexinidazole will decrease the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Avoid or Use Alternate Drug. Coadministration may decrease plasma concentrations of CYP2B6 substrates owing to fexinidazole inducing CYP2B6.fexinidazole and propofol both increase QTc interval. Avoid or Use Alternate Drug. Avoid coadministration of fexinidazole with drugs known to block potassium channels or prolong QT interval.

  • hydrocodone

    hydrocodone, propofol.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation. Increased risk of hypotension if ability to maintain blood pressure has been compromised by a reduced blood volume or concurrent administration of certain CNS depressant drugs (eg, phenothiazines or general anesthetics).

  • isocarboxazid

    isocarboxazid increases levels of propofol by pharmacodynamic synergism. Avoid or Use Alternate Drug.

  • ivosidenib

    ivosidenib will decrease the level or effect of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Avoid coadministration of sensitive CYP2C9 substrates with ivosidenib or replace with alternate therapies. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs.

  • lefamulin

    lefamulin and propofol both increase QTc interval. Avoid or Use Alternate Drug.

  • lonafarnib

    propofol will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Closely monitor for arrhythmias and events (eg, syncope, heart palpitations) since lonafarnib effect on QT interval is unknown.

  • metoclopramide intranasal

    propofol, metoclopramide intranasal.Either increases effects of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient.

  • norepinephrine

    propofol increases levels of norepinephrine by decreasing metabolism. Contraindicated.

  • phenelzine

    phenelzine increases levels of propofol by pharmacodynamic synergism. Avoid or Use Alternate Drug.

  • phenylephrine

    propofol increases levels of phenylephrine by decreasing metabolism. Contraindicated.

  • phenylephrine PO

    propofol increases levels of phenylephrine PO by decreasing metabolism. Contraindicated.

  • pirfenidone

    propofol will increase the level or effect of pirfenidone by affecting hepatic enzyme CYP1A2 metabolism. Avoid or Use Alternate Drug. Avoid; coadministration of pirfenidone and moderate CYP1A2 inhibitors result in moderately increased exposure to pirfenidone; if unable to avoid, decrease dose of moderate CYP1A2 inhibitor

  • ponesimod

    ponesimod, propofol.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Consult cardiologist if considering treatment. Coadministration of ponesimod with drugs that decrease HR may have additive effects on decreasing HR and should generally not be initiated in these patients.

  • rasagiline

    rasagiline increases levels of propofol by pharmacodynamic synergism. Avoid or Use Alternate Drug.

  • rifampin

    rifampin will decrease the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Avoid or Use Alternate Drug.

  • ropeginterferon alfa 2b

    ropeginterferon alfa 2b and propofol both increase Other (see comment). Avoid or Use Alternate Drug. Narcotics, hypnotics or sedatives can produce additive neuropsychiatric side effects. Avoid use and monitor patients receiving the combination for effects of excessive CNS toxicity.

  • selegiline

    selegiline increases levels of propofol by pharmacodynamic synergism. Avoid or Use Alternate Drug.

  • sodium oxybate

    propofol, sodium oxybate.Either increases effects of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • sufentanil SL

    sufentanil SL, propofol.Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

  • tranylcypromine

    tranylcypromine increases levels of propofol by pharmacodynamic synergism. Avoid or Use Alternate Drug.

  • acebutolol

    propofol, acebutolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • alfentanil

    propofol and alfentanil both increase sedation. Use Caution/Monitor.

  • alpelisib

    alpelisib will decrease the level or effect of propofol by pharmacodynamic synergism. Modify Therapy/Monitor Closely.

  • alprazolam

    propofol and alprazolam both increase sedation. Use Caution/Monitor.

  • amitriptyline

    propofol and amitriptyline both increase sedation. Use Caution/Monitor.

  • amobarbital

    propofol and amobarbital both increase sedation. Use Caution/Monitor.

  • amoxapine

    propofol and amoxapine both increase sedation. Use Caution/Monitor.

  • apalutamide

    apalutamide will decrease the level or effect of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Coadministration of apalutamide, a weak CYP2C9 inducer, with drugs that are CYP2C9 substrates can result in lower exposure to these medications. Evaluate for loss of therapeutic effect if medication must be coadministered.

  • apomorphine

    propofol and apomorphine both increase sedation. Use Caution/Monitor.apomorphine and propofol both increase QTc interval. Use Caution/Monitor.

  • atenolol

    propofol, atenolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • atogepant

    propofol will increase the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

    (Video) Propofol - Indications, Mechanism Of Action, Pharmacology, Adverse Effects, And Contraindications

  • avapritinib

    propofol will increase the level or effect of avapritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • axitinib

    propofol increases levels of axitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • baclofen

    propofol and baclofen both increase sedation. Use Caution/Monitor.

  • belladonna and opium

    propofol and belladonna and opium both increase sedation. Use Caution/Monitor.

  • benazepril

    propofol, benazepril.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Increases risk of hypotension.

  • benperidol

    propofol and benperidol both increase sedation. Use Caution/Monitor.

  • betaxolol

    propofol, betaxolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • bisoprolol

    propofol, bisoprolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • brompheniramine

    propofol and brompheniramine both increase sedation. Use Caution/Monitor.

  • buprenorphine

    propofol and buprenorphine both increase sedation. Use Caution/Monitor.

  • buprenorphine buccal

    propofol and buprenorphine buccal both increase sedation. Use Caution/Monitor.

  • buprenorphine, long-acting injection

    propofol increases toxicity of buprenorphine, long-acting injection by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. Cessation of benzodiazepines or other CNS depressants is preferred in most cases. In some cases, monitoring at a higher level of care for tapering CNS depressants may be appropriate. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate.

  • butabarbital

    propofol and butabarbital both increase sedation. Use Caution/Monitor.

  • butalbital

    propofol and butalbital both increase sedation. Use Caution/Monitor.

  • butorphanol

    propofol and butorphanol both increase sedation. Use Caution/Monitor.

  • cannabidiol

    propofol will increase the level or effect of cannabidiol by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Consider reducing the cannabidiol dose when coadministered with a moderate CYP2C19 inhibitor.cannabidiol will increase the level or effect of propofol by decreasing metabolism. Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit CYP2C9 activity. Consider reducing the dose when concomitantly using CYP2C9 substrates.cannabidiol will increase the level or effect of propofol by Other (see comment). Modify Therapy/Monitor Closely. Cannabidiol may potentially inhibit UGT1A9 activity. Consider reducing the dose when concomitantly using UGT1A9 substrates.

  • captopril

    propofol, captopril.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.

  • carbinoxamine

    propofol and carbinoxamine both increase sedation. Use Caution/Monitor.

  • carisoprodol

    propofol and carisoprodol both increase sedation. Use Caution/Monitor.

  • carvedilol

    propofol, carvedilol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • celiprolol

    propofol, celiprolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • cenobamate

    cenobamate will decrease the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Modify Therapy/Monitor Closely. Increase dose of CYP2B6 substrate, as needed, when coadministered with cenobamate.cenobamate, propofol.Either increases effects of the other by sedation. Use Caution/Monitor.

  • chloral hydrate

    propofol and chloral hydrate both increase sedation. Use Caution/Monitor.

  • chlordiazepoxide

    propofol and chlordiazepoxide both increase sedation. Use Caution/Monitor.

  • chlorpheniramine

    propofol and chlorpheniramine both increase sedation. Use Caution/Monitor.

  • chlorpromazine

    propofol and chlorpromazine both increase sedation. Use Caution/Monitor.

  • chlorzoxazone

    propofol and chlorzoxazone both increase sedation. Use Caution/Monitor.

  • cilostazol

    propofol increases toxicity of cilostazol by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Consider decreasing cilostazol dose; moderate CYP2C19 inhibitors may increase serum levels of 3,4-dehydrocilostazol (active metabolite).

  • cinnarizine

    propofol and cinnarizine both increase sedation. Use Caution/Monitor.

  • clemastine

    propofol and clemastine both increase sedation. Use Caution/Monitor.

  • clomipramine

    propofol and clomipramine both increase sedation. Use Caution/Monitor.

  • clonazepam

    propofol and clonazepam both increase sedation. Use Caution/Monitor.

  • clorazepate

    propofol and clorazepate both increase sedation. Use Caution/Monitor.

  • clozapine

    propofol and clozapine both increase sedation. Use Caution/Monitor.

  • codeine

    propofol and codeine both increase sedation. Use Caution/Monitor.

  • cyclizine

    propofol and cyclizine both increase sedation. Use Caution/Monitor.

  • cyclobenzaprine

    propofol and cyclobenzaprine both increase sedation. Use Caution/Monitor.

  • cyproheptadine

    propofol and cyproheptadine both increase sedation. Use Caution/Monitor.

  • dantrolene

    propofol and dantrolene both increase sedation. Use Caution/Monitor.

  • daridorexant

    propofol and daridorexant both increase sedation. Modify Therapy/Monitor Closely. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment.

  • desflurane

    desflurane and propofol both increase sedation. Use Caution/Monitor.

  • desipramine

    propofol and desipramine both increase sedation. Use Caution/Monitor.

  • dexchlorpheniramine

    propofol and dexchlorpheniramine both increase sedation. Use Caution/Monitor.

  • dexfenfluramine

    propofol increases and dexfenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dexmedetomidine

    propofol and dexmedetomidine both increase sedation. Use Caution/Monitor.

    (Video) Propofol |Diprivan | Mechanism of Action | Dosage | Indications | Adverse Effect (English )

  • dextromoramide

    propofol and dextromoramide both increase sedation. Use Caution/Monitor.

  • diamorphine

    propofol and diamorphine both increase sedation. Use Caution/Monitor.

  • diazepam

    propofol and diazepam both increase sedation. Use Caution/Monitor.

  • diazepam intranasal

    propofol will increase the level or effect of diazepam intranasal by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Strong or moderate CYP2C19 inhibitors may decrease rate of diazepam elimination, thereby increasing adverse reactions to diazepam.

  • dichlorphenamide

    dichlorphenamide, propofol.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Both drugs can cause metabolic acidosis.

  • diethylpropion

    propofol increases and diethylpropion decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • difelikefalin

    difelikefalin and propofol both increase sedation. Use Caution/Monitor.

  • difenoxin hcl

    propofol and difenoxin hcl both increase sedation. Use Caution/Monitor.

  • dimenhydrinate

    propofol and dimenhydrinate both increase sedation. Use Caution/Monitor.

  • diphenhydramine

    propofol and diphenhydramine both increase sedation. Use Caution/Monitor.

  • diphenoxylate hcl

    propofol and diphenoxylate hcl both increase sedation. Use Caution/Monitor.

  • dipipanone

    propofol and dipipanone both increase sedation. Use Caution/Monitor.

  • dopexamine

    propofol increases and dopexamine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • dosulepin

    propofol and dosulepin both increase sedation. Use Caution/Monitor.

  • doxepin

    propofol and doxepin both increase sedation. Use Caution/Monitor.

  • doxylamine

    propofol and doxylamine both increase sedation. Use Caution/Monitor.

  • droperidol

    propofol and droperidol both increase sedation. Use Caution/Monitor.

  • elvitegravir/cobicistat/emtricitabine/tenofovir DF

    elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Elvitegravir is a moderate CYP2C9 inducer.

  • esketamine intranasal

    esketamine intranasal, propofol.Either increases toxicity of the other by sedation. Modify Therapy/Monitor Closely.

  • esmolol

    propofol, esmolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • estazolam

    propofol and estazolam both increase sedation. Use Caution/Monitor.

  • ethanol

    propofol and ethanol both increase sedation. Use Caution/Monitor.

  • etomidate

    etomidate and propofol both increase sedation. Use Caution/Monitor.

  • fenfluramine

    propofol increases and fenfluramine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • finerenone

    propofol will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Adjust finererone dosage as needed.

  • flibanserin

    propofol will increase the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Increased flibanserin adverse effects may occur if coadministered with multiple weak CYP3A4 inhibitors.

  • fluphenazine

    propofol and fluphenazine both increase sedation. Use Caution/Monitor.

  • flurazepam

    propofol and flurazepam both increase sedation. Use Caution/Monitor.

  • fluvoxamine

    fluvoxamine will increase the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor.

  • fostemsavir

    propofol and fostemsavir both increase QTc interval. Use Caution/Monitor. QTc prolongation reported with higher than recommended doses of fostemsavir.

  • ganaxolone

    propofol and ganaxolone both increase sedation. Use Caution/Monitor.

  • haloperidol

    propofol and haloperidol both increase sedation. Use Caution/Monitor.

  • hydromorphone

    propofol and hydromorphone both increase sedation. Use Caution/Monitor.

  • hydroxyzine

    propofol and hydroxyzine both increase sedation. Use Caution/Monitor.

  • iloperidone

    propofol and iloperidone both increase sedation. Use Caution/Monitor.

  • imipramine

    propofol and imipramine both increase sedation. Use Caution/Monitor.

  • isavuconazonium sulfate

    propofol will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • ivacaftor

    propofol increases levels of ivacaftor by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor when coadministered with weak CYP3A4 inhibitors .

  • ketamine

    ketamine and propofol both increase sedation. Use Caution/Monitor.

  • ketotifen, ophthalmic

    propofol and ketotifen, ophthalmic both increase sedation. Use Caution/Monitor.

  • labetalol

    propofol, labetalol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • lasmiditan

    lasmiditan, propofol.Either increases effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions.

  • lemborexant

    lemborexant will decrease the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Modify Therapy/Monitor Closely. Monitor CYP2B6 substrate for adequate clinical response. Consider increasing the CYP2B6 substrate dose according to specific prescribing recommendations.propofol will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. See drug monograph for specific dosage modification.lemborexant, propofol.Either increases effects of the other by sedation. Modify Therapy/Monitor Closely. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects.

  • levorphanol

    propofol and levorphanol both increase sedation. Use Caution/Monitor.

  • linezolid

    linezolid increases levels of propofol by pharmacodynamic synergism. Use Caution/Monitor.

    (Video) ATRACURIUM | Atracurium BESYLATE | Indications | DOSAGE | Adverse EFFECTS | Pharmacokinetics

  • lofepramine

    propofol and lofepramine both increase sedation. Use Caution/Monitor.

  • lofexidine

    propofol and lofexidine both increase sedation. Use Caution/Monitor.

  • lomitapide

    propofol increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Lomitapide dose should not exceed 30 mg/day.

  • loprazolam

    propofol and loprazolam both increase sedation. Use Caution/Monitor.

  • lorazepam

    propofol and lorazepam both increase sedation. Use Caution/Monitor.

  • lormetazepam

    propofol and lormetazepam both increase sedation. Use Caution/Monitor.

  • loxapine

    propofol and loxapine both increase sedation. Use Caution/Monitor.

  • loxapine inhaled

    propofol and loxapine inhaled both increase sedation. Use Caution/Monitor.

  • lumacaftor/ivacaftor

    lumacaftor/ivacaftor, propofol. affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2B6 substrates. .lumacaftor/ivacaftor, propofol. affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C9 substrates. .

  • maprotiline

    propofol and maprotiline both increase sedation. Use Caution/Monitor.

  • meperidine

    propofol and meperidine both increase sedation. Use Caution/Monitor.

  • meprobamate

    propofol and meprobamate both increase sedation. Use Caution/Monitor.

  • metaxalone

    propofol and metaxalone both increase sedation. Use Caution/Monitor.

  • methadone

    propofol and methadone both increase sedation. Use Caution/Monitor.

  • methocarbamol

    propofol and methocarbamol both increase sedation. Use Caution/Monitor.

  • metoprolol

    propofol, metoprolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • midazolam

    propofol and midazolam both increase sedation. Use Caution/Monitor.

  • midazolam intranasal

    propofol will increase the level or effect of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Coadministration of mild CYP3A4 inhibitors with midazolam intranasal may cause higher midazolam systemic exposure, which may prolong sedation.midazolam intranasal, propofol.Either increases toxicity of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect.

  • midodrine

    propofol increases and midodrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • mifepristone

    mifepristone will increase the level or effect of propofol by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Monitor.

  • mirtazapine

    propofol and mirtazapine both increase sedation. Use Caution/Monitor.mirtazapine and propofol both increase QTc interval. Use Caution/Monitor.

  • morphine

    propofol and morphine both increase sedation. Use Caution/Monitor.

  • moxonidine

    propofol and moxonidine both increase sedation. Use Caution/Monitor.

  • nabilone

    propofol and nabilone both increase sedation. Use Caution/Monitor.

  • nadolol

    propofol, nadolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • nalbuphine

    propofol and nalbuphine both increase sedation. Use Caution/Monitor.

  • nebivolol

    propofol, nebivolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • nitisinone

    nitisinone will increase the level or effect of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Nitisinone inhibits CYP2C9. Caution if CYP2C9 substrate coadministered, particularly those with a narrow therapeutic index.

  • nortriptyline

    propofol and nortriptyline both increase sedation. Use Caution/Monitor.

  • olanzapine

    propofol and olanzapine both increase sedation. Use Caution/Monitor.

  • opium tincture

    propofol and opium tincture both increase sedation. Use Caution/Monitor.

  • orphenadrine

    propofol and orphenadrine both increase sedation. Use Caution/Monitor.

  • osilodrostat

    osilodrostat and propofol both increase QTc interval. Use Caution/Monitor.

  • oxazepam

    propofol and oxazepam both increase sedation. Use Caution/Monitor.

  • oxycodone

    propofol and oxycodone both increase sedation. Use Caution/Monitor.

  • oxymorphone

    propofol and oxymorphone both increase sedation. Use Caution/Monitor.

  • paliperidone

    propofol and paliperidone both increase sedation. Use Caution/Monitor.

  • papaveretum

    propofol and papaveretum both increase sedation. Use Caution/Monitor.

  • papaverine

    propofol and papaverine both increase sedation. Use Caution/Monitor.

  • penbutolol

    propofol, penbutolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • pentazocine

    propofol and pentazocine both increase sedation. Use Caution/Monitor.

  • pentobarbital

    propofol and pentobarbital both increase sedation. Use Caution/Monitor.

  • perphenazine

    propofol and perphenazine both increase sedation. Use Caution/Monitor.

  • phendimetrazine

    propofol increases and phendimetrazine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenobarbital

    propofol and phenobarbital both increase sedation. Use Caution/Monitor.

    (Video) Propofol/ Diprivan

  • phenylephrine

    propofol increases and phenylephrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • phenylephrine PO

    propofol increases and phenylephrine PO decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor. .

  • pholcodine

    propofol and pholcodine both increase sedation. Use Caution/Monitor.

  • pimozide

    propofol and pimozide both increase sedation. Use Caution/Monitor.

  • pindolol

    propofol, pindolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • primidone

    propofol and primidone both increase sedation. Use Caution/Monitor.

  • procarbazine

    procarbazine increases levels of propofol by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of hypotension.

  • prochlorperazine

    propofol and prochlorperazine both increase sedation. Use Caution/Monitor.

  • promethazine

    propofol and promethazine both increase sedation. Use Caution/Monitor.

  • propranolol

    propofol, propranolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • propylhexedrine

    propofol increases and propylhexedrine decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • protriptyline

    propofol and protriptyline both increase sedation. Use Caution/Monitor.

  • quazepam

    propofol and quazepam both increase sedation. Use Caution/Monitor.

  • quetiapine

    propofol and quetiapine both increase sedation. Use Caution/Monitor.

  • ramelteon

    propofol and ramelteon both increase sedation. Use Caution/Monitor.

  • risperidone

    propofol and risperidone both increase sedation. Use Caution/Monitor.

  • rucaparib

    rucaparib will increase the level or effect of propofol by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Adjust dosage of CYP2C9 substrates, if clinically indicated.

  • secobarbital

    propofol and secobarbital both increase sedation. Use Caution/Monitor.

  • selegiline transdermal

    selegiline transdermal increases levels of propofol by pharmacodynamic synergism. Use Caution/Monitor.

  • sevoflurane

    propofol and sevoflurane both increase sedation. Use Caution/Monitor.

  • sotalol

    propofol, sotalol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • stiripentol

    stiripentol, propofol. affecting hepatic enzyme CYP2B6 metabolism. Modify Therapy/Monitor Closely. Stiripentol is a CYP2B6 inhibitor and inducer. Monitor CYP2B6 substrates coadministered with stiripentol for increased or decreased effects. CYP2B6 substrates may require dosage adjustment.stiripentol, propofol.Either increases effects of the other by sedation. Use Caution/Monitor. Concomitant use stiripentol with other CNS depressants, including alcohol, may increase the risk of sedation and somnolence.

  • sufentanil

    propofol and sufentanil both increase sedation. Use Caution/Monitor.

  • tapentadol

    propofol and tapentadol both increase sedation. Use Caution/Monitor.

  • tazemetostat

    propofol will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • temazepam

    propofol and temazepam both increase sedation. Use Caution/Monitor.

  • thioridazine

    propofol and thioridazine both increase sedation. Use Caution/Monitor.

  • thiothixene

    propofol and thiothixene both increase sedation. Use Caution/Monitor.

  • timolol

    propofol, timolol.Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Risk of hypotension.

  • tinidazole

    propofol will increase the level or effect of tinidazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.

  • topiramate

    propofol and topiramate both increase sedation. Modify Therapy/Monitor Closely.

  • tramadol

    propofol and tramadol both increase sedation. Use Caution/Monitor.

  • trazodone

    propofol and trazodone both increase sedation. Use Caution/Monitor.

  • triazolam

    propofol and triazolam both increase sedation. Use Caution/Monitor.

  • triclofos

    propofol and triclofos both increase sedation. Use Caution/Monitor.

  • trifluoperazine

    propofol and trifluoperazine both increase sedation. Use Caution/Monitor.

  • trimipramine

    propofol and trimipramine both increase sedation. Use Caution/Monitor.

  • triprolidine

    propofol and triprolidine both increase sedation. Use Caution/Monitor.

  • valproic acid

    valproic acid increases effects of propofol by pharmacodynamic synergism. Use Caution/Monitor.

  • warfarin

    propofol will increase the level or effect of warfarin by Other (see comment). Use Caution/Monitor. Warfarin's less potent R-enantiomer is metabolized in part by CYP3A4 (and also CYP1A2 and CYP2C19). Monitor INR more frequently if coadministered with inhibitors of these isoenzymes and adjust warfarin dose if needed.

  • xylometazoline

    propofol increases and xylometazoline decreases sedation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

  • ziconotide

    propofol and ziconotide both increase sedation. Use Caution/Monitor.

  • ziprasidone

    propofol and ziprasidone both increase sedation. Use Caution/Monitor.

  • zotepine

    propofol and zotepine both increase sedation. Use Caution/Monitor.

  • FAQs

    What are the adverse effects of propofol? ›

    Side Effects
    • Blurred vision.
    • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.
    • fast, slow, irregular, or pounding heartbeat or pulse.
    • pounding in the ears.
    • problems with movement.

    What Is propofol Diprivan used for? ›

    Diprivan is used to help you relax before and during general anesthesia for surgery or other medical procedures. Diprivan is used in people 16 years or older to sedate those who are under critical care and need a mechanical ventilator (breathing machine).

    How is propofol dosed? ›

    For most patients, 1.5 - 9 mg Propofol /kg of body mass per hour is required. The infusion can be supplemented with bolus administration of up to 1 mg Propofol/kg of body mass, if a rapid increase in the depth of sedation is required. Lower doses may be necessary for patients in the risk groups ASA III and IV.

    Does propofol cause hypotension? ›

    Propofol is likely to induce hypotension by inhibiting the sympathetic nervous system and by impairing baroreflex regulatory mechanisms 5.

    What are the 3 types of anesthesia? ›

    The different types of anesthesia include the following:
    • Local Anesthesia. Local anesthesia is an anesthetic agent given to temporarily stop the sense of pain in a particular area of the body. ...
    • Regional Anesthesia. ...
    • General Anesthesia.

    Does propofol affect heart rate? ›

    Propofol is known to cause a reduction in BP and HR in humans, and inhibition of sympathetic nerve activity is believed as one major mechanism underlying the propofol-induced hemodynamic depression.

    What are the symptoms of propofol overdose? ›

    Pain at the injection site can occur (use larger veins or premedicate with lidocaine). Anaphylaxis, hypotension, bradycardia, supraventricular tachydysrhythmias, conduction disturbances, cough, bronchospasm, rash, pruritus, and hyperlipidemia may occur.

    Does propofol cause bradycardia? ›

    Results of the review

    In controlled clinical trials, propofol significantly increased the risk of bradycardia compared with other anaesthetics (number-needed-to-harm 11.3; 95% CI 7.7, 21).

    What is the difference between propofol and Diprivan? ›

    Propofol-Lipuro is associated with reduced injection pain compared with Diprivan and also seems to attenuate subsequent injection pain of Diprivan when administered first. The mechanism is unknown, but may be related to a reduction in the concentration of propofol in the aqueous phase.

    Is propofol a sedative or paralytic? ›

    [4] Common sedative agents used during rapid sequence intubation include etomidate, ketamine, and propofol. Commonly used neuromuscular blocking agents are succinylcholine and rocuronium. Certain induction agents and paralytic drugs may be more beneficial than others in certain clinical situations.

    How long does propofol side effects last? ›

    Generally, a continuous infusion intravenous dose of propofol (25 μg/kg/min to 100 μg/kg/min) is used to induce amnesia and light sedation. Patients usually recover within 5 min to 10 min after discontinuation of this infusion.

    Why is propofol given slowly? ›

    The drug should be administered slowly, intravenously, to minimize the negative cardiac and respiratory effects seen after rapid bolus administration. The currently available formulations do not contain preservatives, and sterile technique should be strictly followed during its use.

    What is the max for propofol? ›

    Most adult patients require maintenance rates of 5 to 50 mcg/kg/min (0.3 to 3 mg/kg/h) or higher. Administration should not exceed 4 mg/kg/hour unless the benefits outweigh the risks (see WARNINGS). Dosages of Propofol Injectable Emulsion should be reduced in patients who have received large dosages of narcotics.

    Is there an antidote for propofol? ›

    Propofol Has No Antidote

    As with certain other deep sedation drugs, propofol has no specific reversal agent or antidote.

    What does propofol do to BP? ›

    In young healthy adults, propofol anesthesia causes limited reduction in blood pressure and decreases CBF by approximately 50% by a reduction in neuronal activity.

    Can propofol cause stroke? ›

    Propofol-Induced Hypertriglyceridemia as a Cause of Stroke

    Acutely, however, hypertriglyceridemia may cause pancreatitis with the suspected mechanism relating to plasma hyperviscosity and decreased perfusion.

    Can propofol cause heart failure? ›

    The pronounced hypotensive effects of the fentanyl/propofol combination may lead to significant hypoperfusion and pose an even greater risk to patients with underlying cardiac conditions such as ischemic heart disease.

    What is the strongest anesthesia? ›

    Of the available opioids, fentanyl has a higher therapeutic index than morphine (400 vs 70), and remifentanil has the highest therapeutic index of any opioid or anesthetic (33,000). Remifentanil is the most recent potent synthetic opioid.

    Who is the highest paid anesthesiologist? ›

    The highest-paid anesthesiologist is an obstetric anesthesiologist. Obstetric anesthesia is the highest-paid anesthesiology subspecialty with an average annual salary range from $217,000 to $582,000 a year.

    How do they wake you up from anesthesia? ›

    Long recovery

    Currently, there are no drugs to bring people out of anesthesia. When surgeons finish an operation, the anesthesiologist turns off the drugs that put the patient under and waits for them to wake up and regain the ability to breathe on their own.

    Does propofol affect breathing? ›

    Propofol at a sedative dose can induce a decrease in the tidal volume, an increase in the respiratory rate, and a decrease in the inspiration cycle [2]. It is also known to cause ventilatory depression, such as a decreased ventilatory response or decreased heart beat response to hypoxia [6].

    When should you not use propofol? ›

    Propofol Injectable Emulsion is not recommended for the induction of anesthesia in patients younger than 3 years of age and for the maintenance of anesthesia in patients younger than 2 months of age as safety and effectiveness have not been established.

    Does propofol cause hypoxia? ›

    Propofol increased the depression of the acute hypoxic response after 15 min of hypoxia by approximately 25%. In control and propofol studies, no hypoxic ventilatory decline was generated during exposure to hypoxic pulses.

    Can you give propofol without intubation? ›

    Conclusion. Propofol-based sedation without endotracheal intubation is safe for ESD procedures in the esophagus and stomach with low anesthesia-related complication rates and short hospital stay.

    How long is propofol used for sedation? ›

    Duration of action: An induction dose of propofol will have a clinical effect for approximately 10 minutes. The prolonged or repeated administration will accumulate in peripheral tissues and will cause an increased duration of action. Distribution: Large volume of distribution.

    How much propofol is used for sedation? ›

    Generally, a propofol loading dose of 40 mg to 50 mg is given with further smaller bolus loads (10 mg to 20 mg) to maintain sedation, with a typical total dose between 100 mg and 300 mg.

    How long after propofol do you wake up? ›

    Propofol has a rapid distribution half-life which leads to rapid awakening from a bolus dose of approximately 8–10 minutes.

    Does propofol make you sleep instantly? ›

    You will relax and fall asleep very quickly after propofol is injected. Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are under the effects of propofol.

    What are the 5 P's for intubation? ›

    The sequential process for quickly intubating a patient in an emergency situation is referred to asrapid-sequence intubation. The steps in performing RSI are often described by the six “P's”: preparation, preoxygenation, pretreatment, paralysis and induction, placement of the tube, and postintubation management (Fig.

    Why is propofol discarded after 24 hours? ›

    For continuous IV infusions, manufacturers recommend discarding tubing and any unused portion of propofol after 12 hours. Loftus et al. found that microorganisms from anesthesia providers' hands and equipment commonly serve as significant sources for IV stopcock contamination associated with anesthesia delivery.

    Why is propofol in a glass bottle? ›

    Propofol has been reported to have high stability in glass and relatively high stability up to 24 hours in polyvinyl chloride-based medical plastics.

    Is propofol dosed by weight? ›

    Summary. Although some studies support the use of ABW-based dosing for propofol, the relationship between weight and pharmacokinetic variables such as clearance is nonlinear. Dosing using ABW may result in supratherapeutic concentrations. Thus, weight-based dosing using either IBW or adjusted body weight is preferred.

    Who can push propofol? ›

    If an anesthesiologist or certified registered nurse anesthetist (CRNA) with ACLS training is present, gives the order, and has the management of the patient's airway as their sole responsibility, an RN might feel safe pushing propofol.

    Can propofol cause shock? ›

    Propofol and fentanyl are frequently used during different medical procedures. The cardiovascular depressive effect of both drugs has been well established, but the development of cardiogenic shock is very rare when these agents are used.

    Why is propofol given before intubation? ›

    Purpose: Propofol is known to provide excellent intubation conditions without the use of neuromuscular blocking agents. However, propofol has adverse effects that may limit its use in the critically ill patients, particularly in the hemodynamically unstable patient.

    Why is propofol used in endoscopy? ›

    Propofol is safe and effective for gastrointestinal endoscopy procedures and is associated with shorter recovery and discharge periods, higher post-anesthesia recovery scores, better sedation, and greater patient cooperation than traditional sedation, without an increase in cardiopulmonary complications.

    When would you use propofol infusion? ›

    Clinical uses of Propofol
    1. Induction of general anesthesia in patients ≥ three years old, though it may be used as an induction agent if a child less than three years of age has IV access.
    2. Maintenance of anesthesia in patients > 2 months old.
    3. Sedation during monitored anesthesia care for patients undergoing procedures.
    25 Jul 2022

    What type of medication is propofol? ›

    Propofol is a non-barbiturate sedative, used in hospital settings by trained anesthetists for the induction, maintenance of general anesthesia, and sedation of ventilated adults receiving intensive care, for a period of up to 72 hours.

    What should you check before administering propofol? ›

    General. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. Clinical experience with the use of in-line filters and Propofol Injectable Emulsion during anesthesia or ICU/MAC sedation is limited.

    Do you stop breathing under propofol? ›

    What side effects does propofol have? It can cause a decrease in blood pressure, it can depress or even stop breathing, and it can cause pain on injection.

    Is propofol moderate or deep sedation? ›

    However, a number of potential adverse effects are associated with propofol. It has no analgesic effects; therefore, when used for moderate sedation, propofol frequently has to be administered in amounts to provide deep levels of sedation to allow a painful procedure to be performed.

    Why do you feel so good after propofol? ›

    Since propofol stimulates the dopamine expression in the central reward system, however, it bears a potential risk of addiction and induces addiction-like behavior in animal models. Additionally, a subgroup of healthy volunteers reported having experienced euphoric moods after propofol administration.

    Who is at risk for propofol infusion syndrome? ›

    It is associated with high doses and long-term use of propofol (> 4 mg/kg/h for more than 24 hours). It occurs more commonly in children, and critically ill patients receiving catecholamines and glucocorticoids are at high risk.

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